THE S.H.Y. LAB
NTU, Institute of Biotechnology
國立台灣大學生物科技研究所
P.I. Shu-Han Yu, Ph. D.
游舒涵助理教授
At S.H.Y. LAB, we empower students to ask insightful questions, explore disciplinary boundaries and confront conventional ways of thinking. Check out our site to learn more about all that we have to offer.
ABOUT THE S.H.Y. LAB
The S.H.Y. Lab studies the molecular pathology and tumor immunology at the Institute of Biotechnology, National Taiwan University.
Dr. Shu-Han Yu’s laboratory has a well-defined focus on the immune mechanisms in the tumor microenvironment, adoptive cell therapy, and the potential role of the microbiome in cancer initiation and progression. The S.H.Y. lab has focused on tumor microenvironment of canine and feline. To illustrate the tumor infiltration immune cell components would help to develop therapeutic drugs for incurable diseases such as FISS or Mast cell tumors (MCTs).
In addition, we aim to categorize the tumor immune microenvironments (TIME) of three types of NSCLC: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma by multiplex-IHC. We also plan to perform whole-exome sequencing to identify NSCLC specific TMB. We plan to build up an immune-based diagnostic platform, which can be a better guide to cancer care and contribute to precision medicine in the era of immuno-oncology and combination therapies. The laboratory also focuses on the influence of the microbiome on lung cancer development, progression, and/or resistance to therapy.
Interested in learning more about S.H.Y. LAB? We invite you to keep exploring our website and get in touch with questions about our values, academics, community and more. Join us today!
游舒涵助理教授實驗室研究方向為腫瘤免疫微環境研究Tumor Immune Microenvironment (TIME)。游博士實驗室所建立之腫瘤微環境研究平台，可運用在犬貓腫瘤及疾病治療機轉之探討。亦可整合愛因斯坦計畫中初步在非小細胞肺癌研究成果，配合游博士在微生物學、免疫學以及腫瘤微環境等專長，帶入非小細胞肺癌精準醫療領域中。研究成果將可幫助臨床醫師針對不同病人的腫瘤免疫微環境進行個人化醫療診斷，大幅下修藥物需求與治療花費，同時也能避免高劑量、長期且持續性給予藥物所帶來的副作用。
WE ARE RECRUITING!!
誠徵熱血新人中!!
ABOUT THE P.I.
Dr. Shu-Han Yu is an assistant professor in the Institute of Biotechnology at National Taiwan University. With more than seven years of academic research experience at the Johns Hopkins University, four years of industrial experience, and the first two years at the National Defense Medical Center as an assistant professor, Dr. Yu has been focusing on applying her expertise in translational medicine and molecular pathology to the studies of precision medicine, the potential role of the microbiome in lung carcinogenesis, immunotherapy, and immune components in the tumor microenvironment.
PROJECTS
PROJECT 1: INTEGRATIVE ANALYSIS OF TUMOR MICROENVIRONMENT (TME) IN NON-SMALL CELL LUNG CANCER (NSCLC)
建立整合性非小細胞肺癌精準醫療平台
In this project, multiplex-immunohistochemistry (multiplex-IHC), multiplex-immunofluorescence (multiplex-IF), and in-situ hybridization would be performed to identify the clinicopathological features in NSCLC.
PROJECT 2: LUNG-SPECIFIC NEOANTIGENS IN IMMUNOTHERAPY
1. The relationship between lung-specific neoantigens and tumor immune microenvironment (TIME).
2. Identification of neoantigen-specific T cells for lung cancer.
3. Lung-specific neoantigens in adoptive cell therapy (ACT).
In this project, whole exome sequencing (WES) and RNA seq will be performed to identify NSCLC specific mutations and neoanigens.
PROJECT 3. Targeting Tumor Immune Microenvironment (TIME) for Cancer Therapy in FISS and Mass Cell Tumors (MCTs)
In this project, several molecular pathology techniques would be used to study the tumor microenrironment of multiple cancer types in canine and feline, including immune cell sorting (FACS/MACS/AutoMACS), immunohistochemistry (IHC), multiplex-IHC (Opal), in situ hybridization, multiplex-in situ, and immunofluorescence (IF).
GALLERY
Multiplex Immunohistochemistry (IHC) of NSCLC
SELECTED AWARDS
Young Scholar Fellowship 愛因斯坦計畫, Ministry of Science and Technology, Taiwan, 2018–2023.
Oral Presentation Award, Boston Taiwanese Association, Annual Symposium, USA, 2015.
Singapore-Global Young Scientist Summit, Singapore Government Travel Award, Singapore, 2013.
Excellence in Translational Research, Young Investigator Award, USA, 2012.
Government Scholarship (公費留考) , Ministry of Education, Taiwan, 2010–2012.
Young Scientist Award, 17th East Asia Joint Conference on Biomedical Research, Taiwan, 2010.
EXPERIENCE AND EDUCATION
Ph.D. Pathobiology
Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
2010–2015.
M.S. Biochemistry and Molecular Biology,
National Taiwan University, Taipei, Taiwan. 國立台灣大學醫學院 生化暨分生研究所
2007–2009.
B.S. Plant Pathology and Microbiology,
National Taiwan University, Taipei, Taiwan. 國立台灣大學 植物病理暨微生物學系
2003–2007.
Selected Publications
1. Korangath P, Barnett J, Sharma A, Henderson E, Stewart J, Yu SH, Kandala SK, Yang CT, Caserto JS, Hedayati M, Armstrong TD, Jaffee E, Gruettner C, Zhou XC, Fu W, Hu C, Sukumar S, Simons BW, and Ivkov R. Nanoparticle interactions with immune cells dominate tumor retention and induce T cell-mediated tumor suppression in models of breast cancer. Science Advances. 2019. In press.
2. Yu SH, Maynard JP, Vaghasia AM, De Marzo AM, Drake CG, Sfanos KS. A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth. Prostate. 2019. 79:215-222.
3. Shrestha E, White JR, Yu SH, Kulac I, Ertunc O, De Marzo AM, Yegnasubramanian S, Mangold LA, Partin AW, Sfanos KS. Profiling the urinary microbiome in men with positive versus negative biopsies for prostate cancer. J Urol. 2018. 199:161-171.
4. Sfanos KS, Canene-Adams K, Hempel H, Yu SH, Simons B, Schaeffer A, Schaeffer E, Nelson G, De Marzo AM. Bacterial prostatitis enhances 2-amino-1-methyl-6-phenylimidazo[4,5-β]pyridine (PhIP)-induced cancer at multiple sites. Cancer Prev. Res. 2015. 8:683-692.
5. Yu SH, Zheng Q, Esopi D, Macgregor-Das A, Luo J, Antonarakis SE, Drake CG, Vessella R, Morrissey C, De Marzo AM, Sfanos KS. A paracrine role for IL6 in prostate cancer patients: lack of production by primary or metastatic tumor cells. Cancer Immunol Res. 2015. 3:1175-1184.
6. Le A, Stine ZE, Nguyen C, Afzal J, Sun P, Hamaker M, Siegel NM, Gouw A, Kang BK, Yu SH, Cochran RL, Sailor KA, Song H, Dang CV. Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter. PNAS. 2014. 111:12486-12491.
7. Shinohara DB, Vaghasia AM, Yu SH, Mak TN, Brüggemann H, Nelson WG, De Marzo AM, Yegnasubramanian S, Sfanos KS. A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes. Prostate. 2013. 73:1007-1015.
8. Mak TN*, Yu SH*, De Marzo AM, Brüggemann H, Sfanos KS. Multilocus sequence typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens. Prostate. 2012. 73:770-777. (*co-first author)
MEMBERS
Lab of Immuno-Oncology
CHIH-HUNG YE (D1)
葉致宏
Doctor Student
GUAN-RU PENG (M1)
彭冠儒
Master Student
WEI-CHIEH YU (B4)
尤韋傑
Undergraduate
WEI-TING CHEN (RA)
陳威廷
Previous Member
WEI-CHEN LIN (RA)
林瑋晨
Research Assistant
SUI-YUN HU(M1)胡隨芸
Master Student
CONTACT US
Find us more: https://www.linkedin.com/in/shuhanyu1/
生物科技研究所
台北市長興街81號 4樓 405室
4F, Rm 405, No. 81, Chang-Xing St., Taipei 106, Taiwan
+886-2-33666007 (Office)